NASA Ames Research Center
Jan – Aug 2026 8 monthsMachine Learning Research Intern · Remote
Took spaceflight-signal detection from 0.5 AUROC (chance) to 0.83–0.97 across five tissue types by tracing the old null result to an evaluation flaw, not biology. Built the team's benchmarking harness over 2.3M unified samples.
Aerospace research · Space biology
- Problem
- The standing conclusion was that spaceflight leaves no detectable signal in tissue: detection sat at 0.5 AUROC, no better than chance. The original random train/test splits also leaked batch effects, so models were scoring which lab produced a sample rather than whether it flew.
- Approach
- Traced the null result to an evaluation flaw rather than a biological one, and rebuilt the protocol on study-grouped cross-validation so every model is judged on biology. Built the team's reproducible benchmarking harness, the first fair comparison of foundation models on space biology data, running five foundation models against classical baselines across three tasks on ACCESS GPU clusters, over a 6-stage preprocessing pipeline that unified 2.3M samples with NASA spaceflight RNA-seq into one comparable gene space.
- Impact
- Detection rose from 0.5 to 0.83–0.97 AUROC across five tissue types, overturning the prior conclusion.
- Foundation models
- Benchmarking
- Study-grouped CV
- Batch-effect diagnosis
- RNA-seq
- GPU clusters
- Python